{"id":4011,"date":"2014-11-14T16:29:01","date_gmt":"2014-11-14T15:29:01","guid":{"rendered":"https:\/\/www.egce.universite-paris-saclay.fr\/?page_id=4011"},"modified":"2014-11-14T16:29:01","modified_gmt":"2014-11-14T15:29:01","slug":"genetic-interactions-and-invasive-gene-in-populations","status":"publish","type":"page","link":"https:\/\/www.egce.universite-paris-saclay.fr\/?page_id=4011&lang=en","title":{"rendered":"Invasive Genes and Genetic Interactions in Populations"},"content":{"rendered":"

Topics<\/span><\/h2>\n

The proposed themes are the result of the fusion of projects developed by the different team members. The integration of these themes in one team reflects a common global objective, a striking resemblance in the study scale and in the chosen approaches, and interactions that are being formalised.<\/p>\n

The global objective is to better understand how the different components of the genome act in populations and what are the consequences on genome evolution, its evolvability, and phenotypes that arise.<\/p>\n

Natural selection, mutations and genetic drift are major driving forces of populations and species evolution. Natural selection acts at the phenotype level, which is itself dependant on the interactions between genotype and environment. Inside the genome, the environment can be assimilated with the epigenetic status, the genotype being represented by the genes and their interactions (epistasy). Hence, it is at the genome level but in the context of population that the team project lies.
\nTopics that interest us mostly are evolution and the dynamics of different genetic systems in populations and ultimately at the species scale, the interactions in these systems, epigenetics influence, and the consequences at the phenotypic and adaptive level. Two types of genetic systems are studied: 1) Complex genetic systems, which evolution is still difficult to understand.  They are, on the one hand, gene sets controlling quantitative characteristics, and also  gene networks submitted to epistatic effects or of canalisation, or further on the set of sequences present on a chromosome. 2) Genetic system so called \u00ab\u00a0egoistic systems\u00a0\u00bb which can amplify them-selves in population more rapidly or more efficiently than possible by the mendeleian segregation or darwinian selection. Among them are disruptors of segregation that promote their own transmission at the expense of alternate alleles, or the transposable elements, which replicate faster than the host genome and use sexual reproduction to invade populations.<\/p>\n

The various projects combine in variable amount experimental , bio-informatic and theoretical approaches. The experimental part includes experimental evolution and natural populations analysis combined with morphological analysis, transcriptomics or genomics. Our main model is Drosophila (D. melanogaster<\/em> and D. simulans<\/em>). The bio-informatics  part is aimed at a better understanding of sequences evolution at the scale of genomes and populations.
\nKeywords : <\/span>Transposable elements, meiotic segregation distorter, Drosophila melanogaster<\/span>, Drosophila simulans<\/span>, evolvability<\/p>\n

Propositions de stage dans l’\u00e9quipe<\/span><\/a><\/span><\/h3>\n

 <\/p>\n

Team members<\/span><\/h2>\n

Researchers<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n
\"Aurelie-carre\"<\/a><\/td>\nAur\u00e9lie Hua-Van<\/a>
\nTeam leader<\/strong>
\n Associate Professor at the University Paris-Sud 11 (Orsay)<\/strong>
\nMolecular evolution and evolutionary dynamics of transposable elements in genomes
\nRegulation of  transposable element mariner<\/em> in drosophila<\/em><\/td>\n<\/tr>\n
\"montchamp\"<\/a><\/td>\nCatherine Montchamp-Moreau<\/a>
\nHead of the laboratory <\/strong>
\nCNRS Research Director<\/strong>
\nGenetic conflicts, molecular bases and evolutionary history of sex-ratio<\/em> meiotic distortion, molecular bases of reproductive isolation and adaptation.<\/td>\n<\/tr>\n
\"capy[1]\"<\/a><\/td>\nPierre Capy<\/a>
\nDirector of IDEEV <\/strong>
\nProfessor at the University Paris-Sud (Orsay)<\/strong>;
\nTransposable element mariner<\/span>.
\nEvolution of TE structure.
\nInvasion dynamics and long-term invasion of TEs.<\/td>\n<\/tr>\n
\"david\"<\/a><\/td>\nJean David<\/a><\/strong>
\nEmeritus CNRS Research Director.<\/strong>
\nPhenotypic plasticity
\nTemperature tolerance<\/td>\n<\/tr>\n
\"aulard-widemann-150x150\"<\/a><\/td>\nSylvie Aulard<\/a><\/strong><\/p>\n

Assistant professor at University Paris 6<\/strong> (Universit\u00e9 Pierre et Marie Curie). Cytogenetics, Inversion polymorphism, transposable elements and chromosomal rearrangement, chromosomal evolution<\/td>\n<\/tr>\n

\"lerouzic\"<\/a><\/td>\nArnaud Le Rouzic<\/a><\/strong>
\nCNRS Senior Researcher<\/strong>
\nTheoretical approaches of genome evolution<\/td>\n<\/tr>\n
 \"\"<\/a><\/td>\nCl\u00e9ment Gilbert<\/a><\/strong>
\nCNRS  Researcher<\/strong>
\nHorizontal transfer and transposable elements<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Engineers and Technicians
\n<\/span><\/h3>\n\n\n\n\n\n
\"clavereau2\"<\/a><\/td>\n\n
\"ELEGEM_Robillard\"<\/a><\/td>\n\n
\"ogereau\"<\/a><\/td>\n\n
David Ogereau<\/a><\/strong><\/div>\n
CNRS Engineer<\/strong><\/div>\n
Genetic mapping and polymorphism using DNA markers. Comparative transcriptomics (DNA Chips, real time).<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/h3>\n

PhD students<\/span><\/h3>\n\n\n\n\n\n
<\/a><\/td>\nC\u00e9cile Courret<\/a><\/strong>
\nPhD student, Graduate School \u00ab\u00a0Structure et Dynamique des Syst\u00e8mes Vivants\u00a0\u00bb,  University Paris-Saclay
\nMolecular bases of the genetic conflict caused by sex chromosome segregation distortion in Drosophila simulans<\/em>.<\/strong>Supervisor :<\/strong> Catherine Montchamp-Moreau.<\/td>\n<\/tr>\n
\"\"<\/a><\/td>\nAndreas Odorico<\/a><\/strong>
\nPhD student, Graduate School \u00ab\u00a0Structure et Dynamique des Syst\u00e8mes Vivants\u00a0\u00bb, University Paris-Saclay
\nEvolution of gene regulatory networks: theoretical models vs. empirical data.<\/strong>Supervisor :<\/strong> Arnaud Le Rouzic<\/td>\n<\/tr>\n
\n

\"\"<\/a><\/span><\/h2>\n<\/td>\n

Vincent Loiseau<\/a><\/strong>
\nPhD student, Graduate School \u00ab\u00a0Structure et Dynamique des Syst\u00e8mes Vivants\u00a0\u00bb,  University Paris-Saclay
\nStudy of mechanisms and frequency of virus-mediated horizontal transfers of genetic material between animals<\/strong>Supervisor :<\/strong> Cl\u00e9ment Gilbert<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Former Postdocs<\/span><\/h3>\n

Jean-Tristan Brandenbourg, <\/strong>Post-doctorant IDEEV. Analysis of mariner dynamics in D. melanogaster genome.<\/p>\n

Pierre G\u00e9rard<\/strong>, Post-doctorant sur projet ANR SexChroDrive. Genetic dissection of sex chromosome meiotic drive in Drosophila simulans<\/span>.<\/p>\n

Michele Schiffer<\/strong>, CNRS Post-doctorate fellow. Evolutionary systematics of drosophildae. Currently working at The University of Melbourne with Professor Ary Hoffmann. The effect of cold stress on hsp expression in drosophila.<\/p>\n

Anna Popkova<\/strong>, CNRS Post-doctorate fellow. Candidate genes for the sex-ratio segregation distortion.<\/p>\n

C\u00e9cile Campagne<\/strong>, Engineer on the ANR project TRANSBIODIV. Neutral and functional trans-specific biodiversity: theoretical developments and quantification on model organisms. Molecular polymorphism, phylogeography, molecular basis of adaptation.<\/p>\n

Michel Cazemajor<\/strong>, researcher on the ANR project SELMULTILOC. Population genetics of the sex-ratio segregation distortion system.<\/p>\n

Former PhD. students
\n<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n
\"Maryem\"<\/a><\/td>\nMaryem Bouallegue<\/a><\/strong>
\nPhD student, <\/strong>SDSV Graduate School , University Paris-Saclay\/University of Tunis<\/strong>Supervisor : Pierre Capy<\/td>\n<\/tr>\n
\"photo<\/a><\/td>\nEstelle R\u00fcnneburger<\/a><\/strong>
\nPhD student, SDSV Graduate School (Paris-sud 11 University)<\/strong>
\nEvolution des r\u00e9seaux de g\u00e8nes. Causes et cons\u00e9quences de l’\u00e9volution du ph\u00e9notype.Supervisor : Arnaud Le Rouzic<\/td>\n<\/tr>\n
\"Bastien\"<\/a><\/td>\nBastien Saint-L\u00e9andre<\/a><\/strong>
\nPhD student, SDSV Graduate School (Paris-sud 11 University)<\/strong>
\nR\u00e9gulation de l’\u00e9l\u00e9ment mariner chez les drosophiles.Supervisor : Pierre Capy.<\/td>\n<\/tr>\n
\"moi-150x150\"<\/a><\/td>\nQuentin Helleu<\/a><\/strong>
\nPhD student, SDSV Graduate School (Paris-sud 11 University)<\/strong><\/p>\n
\n

Cartographie g\u00e9n\u00e9tique d’\u00e9l\u00e9ments distorteurs chez Drosophila simulans.<\/p>\n

Supervisor : Catherine Montchamp-Moreau.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

\"\"<\/a><\/td>\nH\u00e9lo\u00efse Bastide<\/a><\/strong>
\nPhD student, GGC Graduate School (Paris-sud 11 University).<\/strong>Evolutionary history of sex-ratio segregation distortion in Drosophila simulans\u00a0\u00bb. Population molecular polyporphism, phylogeography..<\/td>\n<\/tr>\n
\"\"<\/a><\/td>\nDelphine Legrand<\/strong>
\nPhD student, GGC Graduate School (Paris-sud 11 University).<\/strong> .Phylogeography and evolution of drosophila species of the melanogaster subgroup in the Indian Ocean archipelagos. Molecular Polymorphism, phylogeography, molecular basis of adaptation<\/td>\n<\/tr>\n
\"\"<\/a><\/td>\nLucie Fouvry<\/strong>
\nPhD student, GGC Graduate School (Paris-sud 11 University).<\/strong>Molecular basis and evolution of sex-ratio segregation distortion. Currently High school teacher.<\/td>\n<\/tr>\n
\"Gabriel2\"<\/td>\nGabriel Da Luz Wallau<\/strong>
\nPhD student, Universidade Federal de Santa Maria – BRAZIL<\/strong>
\nEvolution and horizontal transfer of mariner element in drosophila sequenced genomes.Supervisor : Pierre Capy\/Elgion Loreto (Brazil)<\/td>\n<\/tr>\n
\"\"<\/a><\/td>\nThibaud Boutin<\/strong>
\nPhD student, GGC Graduate School (Paris-sud 11 University).<\/strong>
\nLong term invasion dynamics of transposable elements, a theoretical approach.
\nTh\u00e8se soutenue le 16 septembre 2010<\/td>\n<\/tr>\n
\"\"<\/a><\/td>\nSophie Picot<\/strong>
\nPhD student, GGC Graduate School (Paris-sud 11 University).<\/strong>
\nActivity of the transposable element mariner<\/span> in natural populations of Drosophila simulans <\/i>
\nTh\u00e8se soutenue en 2008<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Topics The proposed themes are the result of the fusion of projects developed by the different team members. The integration of these themes in one team reflects a common global objective, a striking resemblance in the study scale and in the chosen approaches, and interactions that are being formalised. The global objective is to better […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4003,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-4011","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/4011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4011"}],"version-history":[{"count":0,"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/4011\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/4003"}],"wp:attachment":[{"href":"https:\/\/www.egce.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}